How To Tweak Caffeine Drinks To Help You Focus

Combine Caffeine with Teacrine for More Focus & Less Crash

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Combine Caffeine with Teacrine for More Focus & Less Crash – Thomas DeLauer

Theacrine is a purine alkaloid found in high concentrations in the kucha plant, but can also be found in smaller concentrations in many other plants that contain caffeine

It is very similar to caffeine in both structure and properties, but has a few key differences – no jitters, crash, and habituation that often accompanies caffeine

The main difference between theacrine and caffeine is the addition of a ketone to the imidazole ring, and the addition of a methyl group off the open nitrogen.

Due to these changes, theacrine is longer-acting, has less side effects, and does not build tolerance like caffeine – it’s half-life is more than than 4x greater than caffeine


Theacrine binds to adenosine receptors, like caffeine, and has a different effect depending on the dosage:

A high dosage (48 mg/kg in rats) blocks adenosine receptors – this mechanism counteracts the drowsiness produced by adenosine, just like caffeine

When adenosine binds with a receptor one of its effects to to slow down activity in that cell, thus causing drowsiness – as theacrine binds to more and more adenosine receptors, it prevents adenosine from binding and slowing down activity

However, smaller doses (3 mg/kg in mice) demonstrate the opposite effect by increasing adenosine levels in the brain (hippocampus) and counteracting the stimulatory property of caffeine

This means that theacrine has a biphasic dose response, meaning that it acts as a sedative at lower doses and has stimulatory properties at higher doses


Theacrine consumed at high doses activates the dopamine receptors DRD1 and DRD2 – a it’s a dopamine reuptake inhibitor, meaning theacrine prevents dopamine from being reabsorbed after it is released in the brain, causing overall dopamine levels to rise and improving focus and mood

A study – from the Journal of Dietary Supplements – of 15 healthy participants showed that a single 200-mg dose of theacrine resulted in a subjective increase in energy, focus, concentration, willingness to exercise, motivation to train, and libido


A study from the journal Fitoterapia looked at the anti-inflammatory and analgesic (pain reducing) effects of theacrine (in mice)

Xylene-induced ear edema, acetic acid-induced vascular permeability and lambda-carrageenan-induced paw edema were used to investigate anti-inflammatory activity, and acetic acid-induced writhing and hot-plate tests were used to determine analgesic effect

Oral administration of theacrine (8-32 mg/kg) induced dose-related anti-inflammatory and analgesic effects – on the other hand, oral caffeine administration (8-32 mg/kg) did not show an inhibitory effect on the inhibition of inflammatory response or cause analgesia

Antioxidant Abilities

A study from the Journal of Agricultural and Food Chemistry found that following 7 days of theacrine supplementation subjects (subjects were mice) showed elevated levels of glutathione inside cells

Safety & Side Effects

A study published in Journal of the International Society of Sports Nutrition

60 healthy men and women were placed into one of three groups: placebo (n = 20), 200 mg Teacrine (n = 19) or 300 mg Teacrine (n = 21) and ingested their respective supplement once daily for 8 weeks

All values for clinical safety markers fell within normal limits and no evidence of habituation was noted as baseline values for energy, focus, concentration, anxiety, motivation to exercise, and POMS remained stable in all groups across the 8-week study protocol


1) 6 Interesting Health Benefits of Theacrine – with Dosage and Safety – Selfhacked. (2017, December 12). Retrieved from

2) Ziegenfuss TN , et al. (n.d.). A Two-Part Approach to Examine the Effects of Theacrine (TeaCrine®) Supplementation on Oxygen Consumption, Hemodynamic Responses, and Subjective Me… – PubMed – NCBI. Retrieved from

3) Feduccia AA , et al. (n.d.). Locomotor activation by theacrine, a purine alkaloid structurally similar to caffeine: involvement of adenosine and dopamine receptors. – PubMed – NCBI. Retrieved from

4) Wang Y , et al. (n.d.). Theacrine, a purine alkaloid with anti-inflammatory and analgesic activities. – PubMed – NCBI. Retrieved from

5) Taylor L , et al. (n.d.). Safety of TeaCrine®, a non-habituating, naturally-occurring purine alkaloid over eight weeks of continuous use. – PubMed – NCBI. Retrieved from

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